This report provides an overview of activities under the Nairobi work programme on impacts, vulnerability and adaptation to climate change since May 2020. It documents progress, good practices and challenges in implementing these activities in collaboration with partner organizations and experts. The activities have focused on strengthening the Nairobi work programme as a knowledge-to-action hub on adaptation and resilience and supporting enhanced action on climate resilience. They include creating user-friendly knowledge products; catalysing action in thematic areas such as forests and grasslands, and oceans, coastal areas and ecosystems; advancing work on bridging priority knowledge gaps in countries and subregions under the Lima Adaptation Knowledge Initiative; and collaborating with UNFCCC constituted bodies. The report contains an indicative workplan for 2021–2022 and concludes with next steps for the Nairobi work programme.