This report provides an overview of activities under the Nairobi work programme on impacts, vulnerability and adaptation to climate change since the fiftieth session of the Subsidiary Body for Scientific and Technological Advice. This report documents progress, good practices and challenges in implementing these activities in collaboration with partner organizations and experts. The activities have focused on strengthening the Nairobi work programme as a knowledge-to-action hub on adaptation and resilience as well as supporting enhanced action on climate resilience. They include creating user-friendly knowledge products and catalysing action in the thematic areas of oceans, coastal areas and ecosystems, and biodiversity and climate change adaptation; and advancing work on bridging prioritized knowledge gaps in countries and subregions under the Lima Adaptation Knowledge Initiative. The activities also include ongoing collaboration and support to the work of the constituted bodies under the UNFCCC process. The report contains an indicative workplan for 2020–2021 and concludes with next steps for the Nairobi work programme.