Between 2019 and 2023, the secretariat curated and disseminated knowledge with the aim of advancing both transformational and long-term incremental adaptation under the Nairobi work programme on impacts, vulnerability and adaptation to climate change,including at the regional level, through engagement with Parties, partners (over 450), thematic expert groups, UNFCCC constituted bodies and communities of practice. This report contains information on the evidence-based outcomes of the Lima Adaptation Knowledge Initiative, the UN Climate Change and Universities Partnership Programme, activities in priority thematic areas and engagement with constituted bodies. Five key outcomes are highlighted: establishment of long-term strategic partnerships for regional adaptation action; increased understanding of shared ecosystems and identification of ways to protect them when taking climate action; development and implementation of approaches and tools for risk assessment, adaptation planning, and monitoring and evaluation; provision of technical support to the least developed countries and small island developing States for formulating and implementing national adaptation plans; and fostering of regional collaboration with programme partners to support constituted bodies in implementing their workplans. Lessons learned, remaining challenges and the way forward in relation the Nairobi work programme are also presented.