This report provides an overview of efforts to enhance adaptation action through knowledge, through implementing activities under the Nairobi work programme on impacts, vulnerability and adaptation to climate change since May 2021. It documents progress, good practices and challenges in implementing the activities in collaboration with partner organizations and experts. The activities have focused on assisting countries to scale up adaptation action through knowledge curated under the Nairobi work programme, as the UNFCCC knowledge-to-action hub on adaptation and resilience. Activities include initiating work in the thematic area of agriculture and food security, and catalysing action in the thematic areas of forests and grasslands, and oceans, coastal areas and ecosystems. Action was further catalysed to close priority knowledge gaps in countries and subregions under the Lima Adaptation Knowledge Initiative with subregional networks; fostering collaboration with UNFCCC constituted bodies; and monitoring, evaluating, and learning about adaptation practices and results, including through preparing and disseminating user-friendly knowledge products. This report concludes with next steps for the Nairobi work programme and contains an indicative workplan for 2022–2023 in the annex.